Current Issue : April - June Volume : 2019 Issue Number : 2 Articles : 5 Articles
Background: 6-Shogaol is a constituent of ginger that imparts the pungent flavor and a hydrolysis product of\ngingerols. This study aimed to investigate the potential of 6-shogaol as a natural cosmetic raw material by\nexamining its anti-apoptotic, antioxidant, and anti-aging effects in human dermal fibroblasts (HDFs).\nMethods: Cell cycle analysis, ApoAlert caspase-3 colorimetric assay, and qRT-PCR analysis to assess the anti-apoptotic\neffects and qRT-PCR to measure the expression of SOD, CAT, and NRF2 to assess the antioxidant effects of 6-shogaol\nwere performed; dichlorofluorescein diacetate was used to measure reactive oxygen species (ROS). Anti-aging effects\nwere examined using qRT-PCR analysis to measure the expression of COL1A1 and MMP1 as well as using an SA-beta\nGal assay.......
Background: This study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, nontoxicity,\nand non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean\nwomen, with special emphasis on a development of natural substances with a high safety to relieve acne and\nminimize skin irritation.\nMethods: After a homogeneity test was conducted targeting 20 Korean women with acne skin, who have met the\nprimary and the secondary clinical selection criteria, the subjects were divided into the treatment group with myrtle\nessential oil applied (the experimental group) and the no-treatment group with no myrtle essential oil applied (the\ncontrol group) to use provided cosmetics every morning and evening for 6 weeks. To precisely check the effects of\nthe myrtle substances, the provided cosmetics are made with only a difference in the presence or absence of\nadded myrtle substances, leaving all other substances equal.\nResults: The acne grades significantly decreased in the experimental group with myrtle applied, with the pore index\n(outstanding pores, large pores, blackheads), the erythema index, the sebum index, and the desquamation index also\ndecreased in the group. Lastly, the microorganism index decreased considerably in the experimental group, showing\nall evaluation indicators related to acne improved in the experimental group in a statistically significant manner. On the\nother hand, the acne grades a little decreased in the control group with no myrtle applied, but with no statistical\nsignificance, while the pore index (outstanding pores, large pores, blackheads), the erythema index, the sebum index,\nand the desquamation index rather increased to some extent. In addition, the microorganism index decreased in the\ncontrol group, but with a smaller volume of changes than that in the experimental group.\nConclusion: This study has clinically proved that myrtle essential oil has effects for convergence, reduction in\nerythema, removal of sebum and dead skin cells, and antibacterial activity on the facial skin of Korean women.\nEspecially, this study confirmed that myrtle essential oil is a safe, skin-soothing substance effective for treating acne by\nshowing the oil reduced the number of erythema.\nTrial registration: -Name of the registry: Institutional Review Board of Korea Institute of Dermatological Sciences\n-Trial registration number 1-70005239-AB-N-01-2018-KIDS-AHA043-HR-01\n-Date of registration: March 2, 2018....
Microbial safety is an essential prerequisite of cosmetics, and preservatives are required to\nprevent product spoilage and damage to consumersâ?? health. Consumer concern about the safety of\nsome cosmetic ingredients and the increasing demand for more natural beauty products has driven\ncosmetic industries and formulators to find natural alternatives to replace synthetic preservatives\ncurrently used. In this study, methylglyoxal (MGO, the main factor responsible for the antimicrobial\nactivity of manuka honey) was tested for antimicrobial activity against a panel of selected bacteria\nand mycetes by using conventional microbiological techniques (determination of M.I.C., time-kill\nassay), and its potential preservative in an O/W emulsion was investigated (challenge test). MGO\nshowed a remarkable and fast antibacterial activity (M.I.C. values 0.150â??0.310 mg/mL), while the\ninhibitory activity against fungi was less marked (M.I.C. values 1.25â??10 mg/mL); chitosan has proven\nto be a synergist of antimicrobial effectiveness of MGO. Results of the challenge test showed that\nthe addition of MGO to a cream formulation was efficient against microbial contamination. On the\nbasis of our results, MGO appears to be a good candidate as a cosmetic preservative of natural origin;\nfurther studies are needed to confirm its applicability and its safety....
Hesperidin is one of the most important natural flavonoids, known for its antioxidant,\nanti-inflammatory, anti-mutagenic, and anti-hypertensive properties. Despite its various biological\nactivities, hesperidin is rarely used in the dermo-cosmetic field because of its poor solubility in\nboth water and oil phases that makes difficult formulation, distribution and bioavailability through\nthe skin layers. Moreover, hesperidin is still underestimated in skin care products, and literature\ndata on its stability into a topical formulation are not yet available. In this paper we report the\nsynthesis of five different derivatives of hesperidin and their evaluation in terms of antioxidant,\nantifungal, antiproliferative, and apoptotic effects on human leukemic K562 cells. Preliminary\nantiproliferative effects were considered since hyper-proliferation is involved in several cutaneous\nproblems particularly in the case of photo-exposition and environmental pollution. Esp4 and Esp5\nwere found to be more active in inhibiting K562 cell growth than parent hesperidin. Esp3 exhibited\ndifferent biological properties, i.e., antioxidant activity in the absence of antiproliferative effects....
As described in previous work, the use of synthetic chemical ingredients in modern cosmetics\nis postulated to be a cause of damage to the skin microbiome. The discovery that biodiversity on\nthe human skin is currently the only reliable indicator of skin health, meant that for the first time,\na mechanism to test for healthy skin was possible. Using this mechanism and in collaboration with The\nMedical University of Graz, who carried out the independent study, this work aimed to help answer\nwhether modern day synthetic cosmetics are a main cause of long-term damage to the skin microbiome.\nThirty-two human participants tested three different face washes for their effect on the skinâ??s microbial\ndiversity, along with skin pH, moisture and TEWL (trans-epidermal water loss), washing twice-a-day\nfor four weeks. The upper volar forearm of the volunteers was swabbed at the beginning, two weeks in\nand at the end of the four weeks. 16S rRNA sequencing was used. One leading â??naturalâ?? brand full\nof synthetic ingredients, a leading synthetic brand and a 100% natural face wash were used. Results\ngive the first indications of a link between synthetic ingredients in a cosmetics product and its effect\non skin microbiome biodiversity. It paves the way for future studies on the topic with a larger sample\ngroup, longer test period and standardised methodology to create a universal standard for testing the\nhealth of skin using benchmark diversity values. This can be used in the future to test the effectiveness\nof cosmetics or ingredients on skin health, leading to the restriction in cosmetics of products proven to\nharm the skinâ??s natural environment....
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